RT Journal Article
SR Electronic
T1 The quantitative link of lung clearance index to bronchial segments affected by bronchiectasis
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 82
OP 84
DO 10.1136/thoraxjnl-2017-210496
VO 73
IS 1
A1 Verbanck, Sylvia
A1 King, Gregory G
A1 Zhou, Wenxiao
A1 Miller, Anne
A1 Thamrin, Cindy
A1 Schuermans, Daniel
A1 Ilsen, Bart
A1 Ernst, Caroline W
A1 de Mey, Johan
A1 Vincken, Walter
A1 Vanderhelst, Eef
YR 2018
UL http://thorax.bmj.com/content/73/1/82.abstract
AB In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease.