PT - JOURNAL ARTICLE AU - Soremekun, Seyi AU - Heaney, Liam G AU - Skinner, Derek AU - Bulathsinhala, Lakmini AU - Carter, Victoria AU - Chaudhry, Isha AU - Hosseini, Naeimeh AU - Eleangovan, Neva AU - Murray, Ruth AU - Tran, Trung N AU - Emmanuel, Benjamin AU - Garcia Gil, Esther AU - Menzies-Gow, Andrew AU - Peters, Matthew AU - Lugogo, Njira AU - Jones, Rupert AU - Price, David B TI - Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study AID - 10.1136/thorax-2021-217032 DP - 2023 Jul 01 TA - Thorax PG - 643--652 VI - 78 IP - 7 4099 - http://thorax.bmj.com/content/78/7/643.short 4100 - http://thorax.bmj.com/content/78/7/643.full SO - Thorax2023 Jul 01; 78 AB - Rationale Progressive lung function (LF) decline in patients with asthma contributes to worse outcomes. Asthma exacerbations are thought to contribute to this decline; however, evidence is limited with mixed results.Methods This historical cohort study of a broad asthma patient population in the Optimum Patient Care Research Database, examined asthma patients with 3+eligible post-18th birthday peak expiratory flow rate (PEF) records (primary analysis) or records of forced expiratory flow in 1 s (FEV1) (sensitivity analysis). Adjusted linear growth models tested the association between mean annual exacerbation rate (AER) and LF trajectory.Results We studied 1 09 182 patients with follow-up ranging from 5 to 50 years, of which 75 280 had data for all variables included in the adjusted analyses. For each additional exacerbation, an estimated additional −1.34 L/min PEF per year (95% CI −1.23 to –1.50) were lost. Patients with AERs >2/year and aged 18–24 years at baseline lost an additional −5.95 L/min PEF/year (95% CI −8.63 to –3.28) compared with those with AER 0. These differences in the rate of LF decline between AER groups became progressively smaller as age at baseline increased. The results using FEV1 were consistent with the above.Conclusion To our knowledge, this study is the largest nationwide cohort of its kind and demonstrates that asthma exacerbations are associated with faster LF decline. This was more prominent in younger patients but was evident in older patients when it was related to lower starting LF, suggesting a persistent deteriorating phenotype that develops in adulthood over time. Earlier intervention with appropriate management in younger patients with asthma could be of value to prevent excessive LF decline.Data are available upon reasonable request. The dataset supporting the conclusions of this article was derived from the Optimum Patient Care Research Database (www.opcrd.co.uk). The OPCRD has ethical approval from the National Health Service (NHS) Research Authority to hold and process anonymised research data (Research Ethics Committee reference: 15/EM/0150). This study was approved by the Anonymised Data Ethics Protocols and Transparency (ADEPT) committee – the independent scientific advisory committee for the OPCRD. The authors do not have permission to give public access to the study dataset; researchers may request access to OPCRD data for their own purposes. Access to OCPRD can be made via the OCPRD website (https://opcrd.co.uk/our-database/data-requests/) or via the enquiries email info@opcrd.co.uk.