Univariable Cox regression analysis in cohort 1 (n=103) and cohort 2 (n=108) demonstrating mortality prediction determined by change in various visual CT variables measured with 5-point ordinal scores
| Study cohort | Visual CT variable change | HR | 95% CI | P value |
|
Cohort 1
| Total ILD extent | 1.89 | 1.30 to 2.73 | 0.001 |
| Ground-glass opacity extent | 1.91 | 1.30 to 2.79 | 0.001 | |
| Reticular pattern extent | 1.54 | 1.07 to 2.22 | 0.02 | |
| Honeycombing extent | 2.21 | 1.50 to 3.28 | 0.00007 | |
| Traction bronchiectasis severity | 2.06 | 1.40 to 3.06 | 0.0003 | |
|
Cohort 2
| Total ILD extent | 1.60 | 1.18 to 2.17 | 0.002 |
| Ground-glass opacity extent | 1.40 | 1.00 to 1.97 | 0.054 | |
| Reticular pattern extent | 1.68 | 1.17 to 2.42 | 0.005 | |
| Honeycombing extent | 1.87 | 1.27 to 2.76 | 0.002 | |
| Traction bronchiectasis severity | 2.61 | 1.60 to 4.28 | 0.0001 |
ILD, interstitial lung disease.