Multivariable Cox regression analysis models demonstrating mortality prediction determined by change in various visual CT variables (measured with 5-point ordinal scores) in the combined idiopathic pulmonary fibrosis population (n=211)
| Categorical change in visual CT variables | Visual CT variable (HR, 95% CI, P value, Concordance Index) | FVC decline (HR, 95% CI, P value) |
| Total ILD extent | 1.53, 1.19 to 1.97, 0.004, 0.68 | 0.55, 0.30 to 1.01, 0.053 |
| Ground-glass opacity extent | 1.49, 1.15 to 1.93, 0.01, 0.68 | 0.47, 0.27 to 0.82, 0.008 |
| Reticular pattern extent | 1.41, 1.07 to 1.86, 0.07, 0.68 | 0.53, 0.29 to 0.97, 0.04 |
| Honeycombing extent | 1.66, 1.22 to 2.26, 0.006, 0.68 | 0.52, 0.28 to 0.94, 0.03 |
| Traction Bronchiectasis severity | 1.95, 1.42 to 2.67, 0.0002, 0.69 | 0.52, 0.30 to 0.90, 0.02 |
P values shown are adjusted for multiple comparisons.
Each visual CT variable was analysed in a separate model adjusted for patient age, gender, baseline disease severity using the diffusion capacity for carbon monoxide, antifibrotic use (never/ever) and FVC decline calculated using mixed effects models.
FVC, forced vital capacity; ILD, interstitial lung disease.