Comparison of changes between baseline and each evaluation point in the two groups
12 weeks | 26 weeks | 52 weeks | ||||
Difference† (SE) | P value | Difference† (SE) | P value | Difference† (SE) | P value | |
6 min walking distance | 22.5 (10.1) | 0.029 | 31.7 (12.5) | 0.013 | 20.7 (23.4) | 0.38 |
Endurance time | 344.1 (62.9) | <0.0001 | 271.0 (77.2) | 0.0007 | 186.8 (77.9) | 0.019 |
6 min walking distance, percentage of change | 0.07 (0.02) | 0.0068 | 0.08 (0.03) | 0.0055 | 0.06 (0.05) | 0.28 |
SGRQ total | −1.03 (2.34) | 0.66 | 1.25 (2.74) | 0.65 | −0.20 (3.72) | 0.96 |
SGRQ symptoms | −1.12 (3.43) | 0.75 | −0.71 (3.74) | 0.85 | −5.48 (4.34) | 0.21 |
SGRQ activity | −1.86 (2.96) | 0.53 | 0 (3.19) | 1.00 | 0.52 (4.17) | 0.90 |
SGRQ impact | −0.89 (2.8) | 0.75 | 1.96 (3.33) | 0.56 | 0.66 (4.31) | 0.88 |
COPD assessment test | −1.36 (1.24) | 0.28 | −0.15 (1.54) | 0.92 | −0.97 (1.64) | 0.55 |
Pedometer, step | 274 (401) | 0.50 | 546 (394) | 0.17 | 540 (480) | 0.26 |
Transitional Dyspnoea Index | 2.32 (0.66) | 0.0005 | 1.97 (0.66) | 0.0035‡ | 1.46 (0.67) | 0.032 |
Dyspnoea-12 | −0.48 (1.01) | 0.63 | 0.58 (1.16) | 0.62 | 1.35 (1.51) | 0.37 |
Hospital Anxiety and Depression Scale, Depression | 0.03 (0.61) | 0.96 | −0.16 (0.60) | 0.79 | 0.31 (0.65) | 0.64 |
Hospital Anxiety and Depression Scale, Anxiety | 0.41 (0.60) | 0.50 | −0.2 (0.67) | 0.76 | 0.56 (0.74) | 0.45 |
Saturation of percutaneous oxygen (SpO2), stable | 0.44 (0.30) | 0.15 | 0.42 (0.34) | 0.22 | 0.55 (0.47) | 0.24 |
SpO2, lowest | −0.64 (1.12) | 0.57 | −0.44 (1.07) | 0.69 | 0.07 (1.20) | 0.95 |
FVC | 0.69 (1.64) | 0.68 | 1.08 (1.65) | 0.51 | −1.61 (1.80) | 0.37 |
DLCO | NA | NA | −1.09 (3.79) | 0.77 |
Positive value indicates that the pulmonary rehabilitation group is better.
DLCO, diffuse capacity for carbon monoxide; FVC, forced vital capacity; NA, not applicable; SGRQ, St. George's Respiratory Questionnaire.