Comparison of reference equations in fulfilling study inclusion criteria for INPULSIS and INBUILD studies
| Fulfil neither criteria | Fulfil DLCO criteria only | Fulfil FVC criteria only | Fulfil both criteria | |
| IPF (n=572) | ||||
| ECSC (n=572) | 5 (0.9%) | 10 (1.8%) | 94 (16.4%) | 463 (80.9%) |
| White ancestry (n=478) | 3 (0.6%) | 8 (1.7%) | 77 (16.1%) | 390 (81.6%) |
| Asian (n=76) | 2 (2.6%) | 2 (2.6%) | 12 (2.6%) | 60 (79.0%) |
| Others (n=18) | 0 | 0 | 5 (27.8%) | 13 (72.2%) |
| GLI global (n=541)* | 6 (1.1%) | 18 (3.3%) | 105 (19.4%) | 412 (76.2%) |
| White ancestry (n=450) | 2 (0.4%) | 15 (3.3%) | 92 (20.4%) | 341 (75.8%) |
| Asian (n=73) | 4 (5.5%) | 3 (4.1%) | 9 (12.3%) | 57 (78.1%) |
| Others (n=18) | 0 | 0 | 4 (22.2%) | 14 (77.8%) |
| Non-IPF ILD (n=1413) | ||||
| ECSC (n=1413) | 8 (0.6%) | 24 (1.7%) | 331 (23.4%) | 1050 (74.3%) |
| White ancestry (n=1069) | 5 (0.5%) | 13 (1.2%) | 264 (24.7%) | 787 (73.6%) |
| Asian (n=269) | 3 (1.1%) | 10 (3.7%) | 51 (19.0%) | 205 (76.2%) |
| Others (n=75) | 0 | 1 (1.3%) | 16 (21.3%) | 58 (77.3%) |
| GLI-2017 (n=1377)† | 14 (1.0%) | 62 (4.5%) | 412 (29.9%) | 889 (64.6%) |
| White ancestry (n=1036) | 6 (0.6%) | 40 (3.9%) | 326 (31.5%) | 664 (64.1%) |
| Asian (n=267) | 7 (2.6%) | 17 (6.4%) | 64 (24.0%) | 179 (67.0%) |
| Others (n=74) | 1 (1.4%) | 5 (6.8%) | 22 (29.7%) | 46 (62.2%) |
*The GLI Global reference equation did not apply to 31 patients as they exceeded the age limit for validity.
†The GLI-2017 reference equation did not apply to 36 patients as they exceeded the age limit for validity.
DLCO, diffusing capacity of the lungs for carbon monoxide; ECSC, European Coal and Steel Community; FVC, forced vital capacity; GLI, Global Lung function Initiative; ILD, interstitial lung disease; IPF, idiopathic pulmonary fibrosis.