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Protein kinase G dysfunction is an important factor in induced pulmonary hypertension in mice
  1. En-Ting Chang
  1. Correspondence to Dr En-Ting Chang, Department of Chest Medicine, Buddhist Tzu Chi General Hospital, 707, Sec 3, Chung-Yang Rd., Hualien 970, Taiwan; evan19760202{at}yahoo.com.tw

https://doi.org/10.1136/thoraxjnl-2012-202517

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    In this preclinical study, the authors hypothesised that deficiency of protein kinase G-1 (PKG-1), a serine/threonine kinase, would induce pulmonary hypertension (PH) in mice through Rho A/Rho kinase activation.

    Protein kinase G-1- knockout (Prkg1−/−) mice had decreased PKG-1 and increased pulmonary artery systolic pressure compared …

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    Footnotes

    • Competing interests None.

    • Provenance and peer review Not commissioned; internally peer reviewed.