Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung

Aristides D Tagalakis; Mustafa M Munye; Rositsa Ivanova; Hanpeng Chen; Claire M Smith; Ahmad M Aldossary; Luca Z Rosa; Dale Moulding; Josephine L Barnes; Konstantinos N Kafetzis; Stuart A Jones; Deborah L Baines; Guy W J Moss; Christopher O’Callaghan; Robin J McAnulty; Stephen L Hart

doi:10.1136/thoraxjnl-2017-210670

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Cystic fibrosis

Original article

Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung

Authors

Aristides D Tagalakis Experimental and Personalised Medicine Section, UCL Great Ormond Street Institute of Child Health, London, UK PubMed articles Google scholar articles
Mustafa M Munye Experimental and Personalised Medicine Section, UCL Great Ormond Street Institute of Child Health, London, UK PubMed articles Google scholar articles
Rositsa Ivanova Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK PubMed articles Google scholar articles
Hanpeng Chen Institute of Pharmaceutical Science, Faculty of Life Science and Medicine, King’s College London, London, UK PubMed articles Google scholar articles
Claire M Smith Respiratory, Critical Care and Anaesthesia, UCL Great Ormond Street Institute of Child Health, London, UK PubMed articles Google scholar articles
Ahmad M Aldossary Experimental and Personalised Medicine Section, UCL Great Ormond Street Institute of Child Health, London, UK PubMed articles Google scholar articles
Luca Z Rosa Experimental and Personalised Medicine Section, UCL Great Ormond Street Institute of Child Health, London, UK PubMed articles Google scholar articles
Dale Moulding UCL Great Ormond Street Institute of Child Health, London, UK PubMed articles Google scholar articles
Josephine L Barnes UCL Respiratory Centre for Inflammation and Tissue Repair, London, UK PubMed articles Google scholar articles
Konstantinos N Kafetzis Experimental and Personalised Medicine Section, UCL Great Ormond Street Institute of Child Health, London, UK PubMed articles Google scholar articles
Stuart A Jones Institute of Pharmaceutical Science, Faculty of Life Science and Medicine, King’s College London, London, UK PubMed articles Google scholar articles
Deborah L Baines Institute of Infection and Immunity, St George’s University of London, London, UK PubMed articles Google scholar articles
Guy W J Moss Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK PubMed articles Google scholar articles
Christopher O’Callaghan Respiratory, Critical Care and Anaesthesia, UCL Great Ormond Street Institute of Child Health, London, UK PubMed articles Google scholar articles
Robin J McAnulty UCL Respiratory Centre for Inflammation and Tissue Repair, London, UK PubMed articles Google scholar articles
Stephen L Hart Experimental and Personalised Medicine Section, UCL Great Ormond Street Institute of Child Health, London, UK PubMed articles Google scholar articles

Correspondence to Dr Aristides D Tagalakis, Experimental and Personalised Medicine Section, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK; Aristides.Tagalakis{at}edgehill.ac.uk

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Citation

Tagalakis AD, Munye MM, Ivanova R, et al

Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung

Thorax 2018;73:847-856.

Publication history

Received June 20, 2017
Revised April 8, 2018
Accepted April 9, 2018
First published May 10, 2018.

Online issue publication

September 01, 2022

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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