You are here

Article Text

Article menu
Download PDFPDF
Brief communication
Prognostic accuracy of a peripheral blood transcriptome signature in chronic hypersensitivity pneumonitis
  1. Evans R Fernández Pérez1,
  2. Laura D Harmacek2,
  3. Brian P O'Connor2,
  4. Thomas Danhorn3,
  5. Brian Vestal2,
  6. Lisa A Maier4,
  7. Tilman L Koelsch5,
  8. Sonia M Leach2
  1. 1 Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health Department of Medicine, Denver, Colorado, USA
  2. 2 Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA
  3. 3 Biostatistics and Bioinformatics Shared Resource, University of Colorado Cancer Center, Auroa, Colorado, USA
  4. 4 Division of Occupational Health and Environmental Health Sciences, National Jewish Health Department of Medicine, Denver, Colorado, USA
  5. 5 Thoracic Radiology, National Jewish Health, Denver, Colorado, USA
  1. Correspondence to Dr Evans R Fernández Pérez, Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health Department of Medicine, Denver, Colorado, USA; fernandezevans{at}njhealth.org

Abstract

The prognostic value of peripheral blood mononuclear cell (PBMC) expression profiles, when used in patients with chronic hypersensitivity pneumonitis (CHP), as an adjunct to traditional clinical assessment is unknown. RNA-seq analysis on PBMC from 37 patients with CHP at initial presentation determined that (1) 74 differentially expressed transcripts at a 10% false discovery rate distinguished those with (n=10) and without (n=27) disease progression, defined as absolute FVC and/or diffusing capacity of the lungs for carbon monoxide (DLCO) decline of ≥10% and increased fibrosis on chest CT images within 24 months, and (2) classification models based on gene expression and clinical factors strongly outperform models based solely on clinical factors (baseline FVC%, DLCO% and chest CT fibrosis).

  • hypersensitivity pneumonitis

https://doi.org/10.1136/thoraxjnl-2020-214790

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors ERFP, LDH, BPO'C, TD and SML were involved in study conception and design. Data collection, analysis and drafting the manuscript for important intellectual content were done by ERFP, BV, LDH, BPO'C, LAM, TD, TLK and SML.

    • Funding Supported by NIH/NHLBI grant R01HL148437, a National Jewish Health grant as well as by a generous donation from Forrest Shook.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    Linked Articles

    • Airwaves
      Highlights from this issue
      The Triumvirate
      Thorax 2021; 77 1-1 Published Online First: 16 Dec 2021. doi: 10.1136/thoraxjnl-2021-218543