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Tuberculosis
Original research
Challenging the gold standard: the limitations of molecular assays for detection of Mycobacterium tuberculosis heteroresistance

Authors

  • Sarah N Danchuk Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada McGill International TB Centre, McGill University, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • Ori E Solomon Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada McGill International TB Centre, McGill University, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • Thomas Andreas Kohl Molecular and Experimental Mycobacteriology, Research Center Borstel Leibniz Lung Center, Borstel, Schleswig-Holstein, Germany PubMed articlesGoogle scholar articles
  • Viola Dreyer Molecular and Experimental Mycobacteriology, Research Center Borstel Leibniz Lung Center, Borstel, Schleswig-Holstein, Germany PubMed articlesGoogle scholar articles
  • Ivan Barilar German Centre for Infection Research, Research Centre Borstel, Borstel, Germany PubMed articlesGoogle scholar articles
  • Christian Utpatel Molecular and Experimental Mycobacteriology, Research Center Borstel Leibniz Lung Center, Borstel, Schleswig-Holstein, Germany PubMed articlesGoogle scholar articles
  • Stefan Niemann Research Center Borstel Leibniz Lung Center, Borstel, Schleswig-Holstein, Germany PubMed articlesGoogle scholar articles
  • Dick van Soolingen RIVM, Bilthoven, The Netherlands PubMed articlesGoogle scholar articles
  • Richard Anthony RIVM, Bilthoven, The Netherlands PubMed articlesGoogle scholar articles
  • Jakko van Ingen Radboudumc, Nijmegen, Gelderland, The Netherlands PubMed articlesGoogle scholar articles
  • Joy S Michael Microbiology, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India PubMed articlesGoogle scholar articles
  • Marcel A Behr Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada McGill International TB Centre, McGill University, Montreal, Quebec, Canada Department of Medicine, McGill University, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Marcel A Behr, McGill University, Montreal, Québec H4A 3J1, Canada; marcel.behr{at}mcgill.ca
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Citation

Danchuk SN, Solomon OE, Kohl TA, et al
Challenging the gold standard: the limitations of molecular assays for detection of Mycobacterium tuberculosis heteroresistance
Thorax 2024;79:670-675.

Publication history

  • Received March 3, 2023
  • Accepted January 8, 2024
  • First published January 29, 2024.
Online issue publication 
June 14, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.