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Asthma
Association between vitamin D status at 3 years and eosinophilic asthma in 6-year-old children with a history of severe bronchiolitis
  1. George Doumat1,2,
  2. Joumane El Zein1,
  3. Geneva D Mehta3,
  4. Zhaozhong Zhu1,
  5. Janice A Espinola1,
  6. Ashley F Sullivan1,
  7. Kohei Hasegawa1,
  8. Carlos A Camargo Jr1
  1. 1 Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
  2. 2 Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
  3. 3 Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA
  1. Correspondence to Professor Carlos A Camargo, Jr; ccamargo{at}mgb.org

Abstract

The association between early childhood serum 25-hydroxyvitamin D (25(OH)D) and eosinophilic asthma remains unclear. We investigated this association using multicentre prospective data from 584 children with a history of bronchiolitis requiring hospitalisation (high-risk population). Low serum 25(OH)D levels (<20 ng/mL) were associated with increased odds of developing eosinophilic asthma (adjusted OR 2.33; 95% CI 1.23, 4.40; p=0.01) as compared with children with serum 25(OH)D of 20–39.9 ng/mL. Our data facilitate further investigation into the potential role of early-life vitamin D supplementation among children with a history of severe bronchiolitis and eosinophilia for preventing childhood asthma.

  • Asthma

https://doi.org/10.1136/thorax-2024-222099

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    Footnotes

    • X @GeorgeDoumatMD

    • Contributors GD conceptualised and designed the study, carried out the analyses, drafted the initial manuscript, and critically reviewed and revised the manuscript. JEZ assisted with study design, drafted the initial manuscript and critically reviewed and revised the manuscript. JAE assisted in the statistical analyses and critically reviewed and revised the manuscript. AFS, ZZ and KH contributed to the data collection and critically reviewed and revised the manuscript. GDM assisted with study design, data collection and critically reviewed and revised the manuscript. CAC conceptualised and designed the study, supervised data collection and analysis, and critically reviewed and revised the manuscript. CAC and GD are the guarantors of this work.

    • Funding The study was supported by NIH grants U01 AI087881, R01 AI114552, R01 AI127507 and UH3 OD023253. GDM was supported by NIH grant T32 AI007306. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.